Chromosome 20 is one of the 23 pairs of chromosomes in humans. It is flanked by sugp1 a surp and g patch domain containing protein thought to play a role in premrna splicing and hapln4 a hyaluronan and proteoglycan link protein 4 that binds to hyaluronic acid and may be involved in formation of the extracellular matrix genes upstream and downstream respectively. The evolutionarily conserved tough protein is required for. Gpatch domain containing gpatch gene family hugo gene. Hect and rld domain containing e3 ubiquitin protein ligase 4. Pleckstrin homology domain containing, family g member 2 plekhg2 is a protein that in humans is encoded by the plekhg2 gene. Pdf gpatch domain and kow motifscontaining protein. An important paralog of this gene is ensg00000273154. Complete information for gpatch4 gene protein coding, gpatch domain containing 4, including. The gpatch is a glycinerich domain discovered by sequence alignment, involved in proteinprotein and proteinnucleic acid interaction. Rbm10, rna binding motif protein 10, s11, dxs8237e, kiaa0122, zranb5. Human dan26eprot, a multidomain protein, which, in addition to the gpatch domain, contains an rna polymerase ii cterminal repeatbinding domain seen in many proteins of the polyaaddition machinery.
G patch domain containing protein 8 is a protein that in humans is encoded by the gpatch8 gene. How premrna processing is regulated is in large enigmatic. Protein annotations for g patch domaincontaining protein. Gene ontology go annotations related to this gene include nucleic acid binding and sequencespecific dna binding.
Complete information for gpatch1 gene protein coding, g patch domain containing 1, including. Gpkow gpatch domain and kow motifscontaining protein. Protein annotations for g patch domaincontaining protein 4. Cultured podocytes either differentiated or undifferentiated were lysed in lysis buffer containing 8m urea and were subjected to intip scx fractionation. G patch domain containing 10, hlabassociated transcript 4, ankyrin repeat domaincontaining protein 59, g patch. Csa3g585930 gene cucumber chinese long v2 cucurbit. G patch domain containing 4 hgnc symbol chromosome. Af mice were injected with tamoxifen from p1 to p3, then retinas were collected at p6. Chromosome 20 spans around 63 million base pairs the building material of dna and represents between 2 and 2. Looking for online definition of zinc finger and btb domain containing protein 6 in the medical dictionary. It is flanked by sugp1 a surp and gpatch domaincontaining protein thought to play a role in premrna splicing and hapln4 a hyaluronan and proteoglycan link protein 4 that binds to hyaluronic acid and may be involved in formation of the extracellular matrix genes upstream and downstream respectively. G patch domaincontaining protein 8 is a protein that in humans is encoded by the gpatch8 gene.
Gpatch domain and kow motifscontaining protein, gpkow. Gpatch8 g patch domaincontaining protein 8 homo sapiens. Gpatch2 g patch domain containing 2 is a protein coding gene. The cultured podocyte proteomic database cpodoprot contains proteins revealed by mass spectrometry analysis of cultured mouse podocytes reference. Looking for online definition of zinc finger and btb domaincontaining protein 6 in the medical dictionary.
Zinc finger and btb domaincontaining protein 6 definition. Gpatch2 gpatch domain containing 2 is a protein coding gene. Please select a link in the alphabetical index to find a protein fam. Tgh contains two conserved protein domains found in proteins with a role in rna binding and. The gram domain has been found in a wide range of organisms from prokaryotes to eukaryotes. The g patch is a glycinerich domain discovered by sequence alignment, involved in protein protein and protein nucleic acid interaction. Oct 03, 2019 quantifications of indicated protein expression f. Gpatch4 gene genecards gptc4 protein gptc4 antibody.
G patch domain containing protein 2 gpatch2, bsd domain containing protein 1 bsdc1, pleckstrin homology domain containing family j member 1 plekhj1, wd repeat and sof domain containing protein 1 wdsof1. Gpatch domain ipr000467 interpro entry interpro emblebi. An autosomal dominant disorder of connective tissue with abnormal features in the heart, the eye, and the skeleton. The g patch domain consists of a conserved pattern of glycines and is thought to possess rnabinding affinity. Human luca15, a multidomain rnabinding protein that is the product of a gene deleted in certain lung tumors. Gpatch2 g patch domaincontaining protein 2 homo sapiens. Sugp2 surp and gpatch domaincontaining protein 2 homo. Marfan syndrome ontology report rat genome database. G patch domaincontaining protein 8 is a protein that in humans is encoded by the gpatch8 gene hyperuricemia. Atlas of genetics and cytogenetics in oncology and haematology home genes leukemias solid tumors cancerprone deep insight case reports journals portal teaching. Sequences from gpatch protein partners of deahrha helicases from human and yeast are in the red.
Pdf regulation of deahrha helicases by gpatch proteins. Gpatch8 on chromosome 17 were identified that cosegregated with hyperuricemia in. Nacetylglucosamine1phosphotransferase subunits alphabetanacetylglucosamine1phosphate transferase alpha and beta subunits, stealth protein gnptab. Omim entry 614396 gpatch domaincontaining protein 8. Rna helicases from the deahrha family are present in all the processes of rna metabolism. Tm6sf2 is located on chromosome 19 precisely at locus 19p. Spp382prp43, the gpatch domain of nkrf and the cterminal obfold of dhx15 primarily mediate the association between these proteins. Meaning of zinc finger and btb domain containing protein 6 medical term.
Proteins containing gpatch domains, such as gpatch2, are implicated in rna processing summary by lin et al. Ccdc75, g patch domaincontaining protein 11coiledcoil domain containing 75. Gpatch8 gene genecards gptc8 protein gptc8 antibody. All positional information in this entry refers to it. We find that dhx15 also interacts with the human gpatch protein nkrf and that, as for other gpatch proteinhelicase interactions e. Diseases associated with gpatch2 include lymphogranuloma venereum and granuloma inguinale. A phosphorylation status of hos5 is controlled by fry2.
Tgh contains domains with strong similarity to gpatch and swap domains, protein domains that are. Pdf gpatch domain and kow motifscontaining protein, gpkow. Ipr011666 g patch domaincontaining protein, nterminal. What is zinc finger and btb domaincontaining protein 6. What is zinc finger and btb domain containing protein 6. Predicted intracellular proteins intracellular proteins predicted by mdm and mdsec. Hyperuricemia cosegregating with osteogenesis imperfecta has been shown to be associated with a mutation in gpatch8 using exome sequencing. Omim entry 616836 gpatch domaincontaining protein 2. Chromosome 20 was fully sequenced in 2001 and was reported to contain over 59 million base pairs representing 99.
Gpatch11, gpatch domain containing 11 orthology source. Posttranscriptional processing of premrna takes place in several steps and requires involvement of a number of rnabinding proteins. Gene ontology go annotations related to this gene include nucleic acid binding. Gpatch1 gene genecards gptc1 protein gptc1 antibody. This isoform has been chosen as the canonical i sequence.
Nursa occasionally sends newsletters describing updates to the website, new datasets, funding opportunities, meetings, etc. Gpatch8 gpatch domain containing 8 is a protein coding gene. G patch domain and ankyrin repeats 1 gpank1 antikorper. Isolectin b4 and esm1 staining of p6 retinas isolated from wtpka with wtatg5 or atg5 ecko mice and dnpka iec with wtatg5 or atg5 ecko mice. Diseases associated with zgpat include gingival hypertrophy and noonan syndrome 1. The phosphorylated hos5p and unphosphorylated hos5 bands of hos5 were detected by antiflag antibody phostag. Gpatch4 protein expression summary the human protein atlas. Gg endothelial cells isolated from mice wild type or dnpka iec were lysed in ripa buffer and atg16l1 protein was analyzed by western blot g. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the gpatch domain and kow motifscontaining protein gpkow, also known as the t54 protein or mos2 homolog, as an interaction partner for cbeta2. G proteincoupled receptor and g proteins working together transmit signals from many hormones. Zinc finger dhhc domaincontaining protein 17 definition. The function of two helicases from this family, prp2 and prp43, is regulated by protein partners containing a gpatch domain. Zinc finger ccchtype with g patch domaincontaining protein. This is also the sequence that appears in the downloadable versions of the entry.
Gpatch8, gpatch domain containing 8, kiaa0553, gpatc8, 17q21. Zinc finger dhhc domaincontaining protein 17 definition of. Meaning of zinc finger and btb domaincontaining protein 6 medical term. Ccdc75, g patch domain containing protein 11coiledcoil domain. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool. Figures and data in endothelial pka activity regulates. G patch domain and kow motifs containing protein, gpkow. We can not exclude the possibility that gpkow also binds dna in addition to rna since other gpatch domain containing proteins have been shown to be involved in dna repair and telomere maintenance 46, 42, 47 as well as rnaprocessing 48, 49. Interpro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.
Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the g patch domain and kow motifscontaining protein gpkow, also known as the t54 protein or mos2 homolog, as an interaction partner for cbeta2. Rnabinding protein hos5 and serineargininerich proteins. The gpatch domain consists of a conserved pattern of glycines and is thought to possess rnabinding affinity. Two missense singlenucleotide variants in zpbp2 and gpatch8 on chromosome 17 were identified that cosegregated with hyperuricemia in the japanese family. Browse our g patch domain and ankyrin repeats 1 proteins. Gpatch2 gene genecards gptc2 protein gptc2 antibody. Complete information for gpatch1 gene protein coding, gpatch domain containing 1, including. Gem, a member of the gram domain family of proteins, is. Sequences from g patch protein partners of deahrha helicases from human and yeast are in the red.
Zinc finger ccchtype with g patch domaincontaining protein 53 signal recognition particle receptor subunit alpha homolog 53 claspin homolog 53 26s proteasome nonatpase regulatory subunit 4 53 titin 53 40s ribosomal protein s10b 53 dna primase small subunit 52 protein shuttle craft 52 calciumcalmodulindependent protein kinase type ii alpha. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the g patch domain and kow motifs containing protein gpkow, also known as the t54 protein or mos2 homolog, as an interaction partner for cbeta2. G patch domaincontaining protein 2 gpatch2, bsd domaincontaining protein 1 bsdc1, pleckstrin homology domaincontaining family j member 1 plekhj1, wd repeat and sof domaincontaining protein 1 wdsof1. G patch domain and ankyrin repeat containing protein 1, g patch domain and ankyrin repeats containing protein 1, g patch domain containing 10, hlabassociated transcript 4, ankyrin repeat domain containing protein 59, g patch domain containing protein 10, protein bat4, protein g5, hlab associated transcript 4. The function of two helicases from this family, prp2 and prp43, is regulated by protein partners containing a g patch domain. A mutation in the serinerich region of the protein is thought to be associated with.
Proteins containing g patch domains, such as gpatch2, are implicated in rna processing summary by lin et al. Gem belongs to a subfamily of the gram domaincontaining proteins. The catalytic c subunit of protein kinase a pka is a serinethreonine kinase, which regulates numerous cellular processes including premrna splicing. G patch domain and ankyrin repeatscontaining protein 1, g patch domain containing 10, hlabassociated transcript 4. G patch domain and ankyrin repeats 1 gpank1 antibodies. Here you may search for taed protein families through an alphabetical search. Activated rna polymerase ii transcriptional coactivator p15. Zgpat zinc finger ccchtype and g patch domain containing is a protein coding gene. We can not exclude the possibility that gpkow also binds dna in addition to rna since other g patch domain containing proteins have been shown to be involved in dna repair and telomere maintenance 46, 42, 47 as well as rnaprocessing 48, 49. Observational study of genedisease association, geneenvironment interaction, and pharmacogenomic toxicogenomic. Zgpat zinc finger ccchtype and gpatch domain containing is a protein coding gene. Doublestranded rnabinding protein staufen homolog 2.
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